What is Epiduo Gel?

Epiduo comes in a gel form and acts as a treatment of acne. The brand is produced by Galderma SA and can only be obtained with a prescription. It’s currently the most prescribed topical acne treatment. The drug is a combination of adapalene (a retinoid) and benzoyl peroxide (an antiseptic). There are seven forms of retinoid available for skin care. Adapalene is a synthetic retinoid, which means it’s more stable and reliable than natural forms. Benzoyl peroxide is a common acne treatment that fights bacteria and shrinks the pimple.

How does Epiduo gel work?

Epiduo contains 0.1% adapalene and 2.5% benzoyl peroxide. Together, acne basically doesn’t stand a chance. The benzoyl peroxide kills the bacteria that causes acne. Adapalene has several acne-fighting actions. It unclogs the blocked pores, ridding them of bacteria that the benzoyl peroxide has killed, as well as other debris and excess oil. Adapalene also reduces redness and inflammation that are commonly associated with acne. 

How is it available?

Epiduo gel requires a doctor’s prescription. Usually it’s only prescribed after over-the-counter treatments have been tried and failed to effectively treat the acne. It’s available in most retail pharmacies across the country.  

How does one use Epiduo?

epiduo gel

Epiduo gel is a topical medication, which means that it is applied directly on skin. Before applying the medication, wash your hands and gently clean the skin with a gentle face cleanser to remove the excess oil and debris. Pat the skin dry and apply a very thin layer of the gel with your finger or a Q-tip. Apply to skin just once a day, at the same time every day. Apply moisturizer after the gel has dried, to prevent skin surrounding the affected area from becoming dry and irritated.


Related: How Do Epiduo and BenzaClin Gel Compare?

What are side effects of Epiduo?

When Epiduo gel is initially applied, it may cause redness, peeling of skin, dryness, and a mild burning sensation. Applying a moisturizer after the gel dries should help reduce these symptoms, which should recede on their own after a few weeks of treatment. If these side effects continue to bother you, talk to your doctor.

At first, it may appear that the acne is getting worse. Most likely, this is only temporary last two to three weeks at the most. After that point, your acne should begin to gradually clear up.

Can Epiduo gel cause an allergic reaction?

Like any drug, there is always a risk of an allergic reaction. If you develop facial swelling, tingling around the lips, dizziness, difficulty breathing, and/or a rash, stop the treatment immediately and seek immediate medical assistance.

What precautions should I take when using this drug?

When discussing the use of Epiduo with your doctor, be sure to inform him or her if you have:

Using this gel will cause a reaction if you’re allergic to either of its main ingredients. It may also increase dryness and itching for those who deal with eczema or dermatitis.

Epiduo gel may bleach hair or stain fabrics. To avoid both, don’t apply the gel near the hairline and use a headband to keep if out of your face while the medication dries. If you apply the medication at night, use an old pillow case or place a towel on your pillow to avoid staining.

Retinoids cause sensitivity to UV rays, which means Epiduo make your skin more sensitive to sunlight. Avoid prolonged sun exposure and the use of sun lamps and tanning beds. When you go outside, wear sunscreen or a moisturizer with a high SPF. Avoid applying the gel when you have a sunburn, as it can irritate the skin further. Extreme weather, like intense heat or cold, can also increase irritation of skin where the gel is used.

Cosmetic procedures like chemical peels will react negatively with Epiduo treatment. Talk to your doctor before having any cosmetic procedures done. Other acne treatments may also worsen you skin’s condition. Products like that contain alcohol, fragrances, and microbeads may irritate the treated area. Similarly, any additional spot treatment may do more harm than good.  

Avoid this gel if: you skin is cut, burnt, lacerated, or if you’re pregnant or planning to become pregnant. Avoid applying this treatment in any bodily orifices.

Can Epiduo gel interact with other medications?

Because Epiduo gel is applied on the skin, the risk of interactions with other medications is low. Nevertheless, tell your healthcare provider about all the prescription and non-prescription medications you take, including herbal supplements. Never change the dose of any medication without first speaking to your healthcare provider.

Can anyone use Epiduo?

Only those over nine years of age who are dealing with mild to moderate acne should use drug. Women who are pregnant, may become pregnant, or are breastfeeding should avoid this treatment, as the effects on infants is unknown.

Does it work?

Based on clinical studies, the majority of individuals with acne had a very favorable result with minimal side effects when using this treatment. At the end of the study which lasted from twelve weeks to twelve months, most patients had noticeably improved skin.

Are there any Epiduo gel reviews?

Yes, there many online reviews. One can read the reviews on drugs.com and on rxlist.com. The majority of reviews on this gel are positive. The few negative reports about the drug talk about the adverse reactions like redness and skin peeling which lasted 2-3 weeks. There are also some reports indicating that it did not work. In most of these cases, individuals expected immediate results and did not use the treatment for the prescribed amount of time. 

How fast does Epiduo work?

It can take as little as a few weeks, up to a few months to erase acne.  Most people began to see clear younger and fresher looking skin in 4-6 weeks. The results are sustained for long periods. 

What if I miss applying Epiduo for one day?

If you miss an application for a single day, it will not make much of a difference in the outcome. However, don’t double the dose the next day. Applying the gel in excess will result in dry, irritated, painful skin.

How should I store it?

Epiduo gel should be stored in a dry place at room temperature. It should be kept away from direct sunlight and heat. Always keep the medication out of reach of children.

Is there a generic version of Epiduo?

To date there is no generic version of Epiduo gel on the market. The FDA has only approved Epiduo for treatment of acne. There are some online pharmacies that claim to have a generic form but this is most likely a scam. Because of fake and counterfeit products, always purchase your prescriptions from a reputable pharmacy.