What is Ziana?

Ziana is a medication used for the treatment of acne. This unique formula is a blend of two other acne medications: tretinoin and clindamycin. It has been realized that the most effective way to treat acne is to use combination agents which have different mechanisms of action. It can be used for treatment of acne in both men and women. It should not be used to treat children under the age of 12.

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How does Ziana work?

Ziana contains clindamycin and tretinoin. Clindamycin is an antibiotic that kills the bacteria known to cause acne. Tretinoin is a vitamin A derivative (also known as a retinoid). It has several actions that help get rid of acne. It acts like a chemical peel; removes the dead skin and replaces it with fresh, newer and younger looking skin. In addition, tretinoin decreases the secretion of oil by the skin glands and that helps prevent plugging up of the pores. Tretinoin also has anti-aging benefits and helps tighten the skin and reduces development of fine lines.

How do I use Ziana?

Ziana gel is applied once a day to the affected area. The medication is best applied just before bedtime. Wash the face with warm water and a mild detergent or soap. Pat the skin dry. Then apply a very light film of the medication on the acne lesion. Gently massage the medication in circles with 2-3 light strokes. If you prefer, you may use a Q-tip. Wash your hands before and after application. There is no need to cover the area with any garment or bandage. After application of the gel, do not wash the face for the next 3-4 hours.

What are side effects of Ziana?

In general, this is a relatively safe medication. However, when initially applying Ziana gel, you may develop the following side effects: mild skin irritation, dryness of skin, peeling of skin, redness, and itching. These side effects are usually due to the peeling actions of tretinoin and last only a few days. If the side effects are mild to moderate, one can apply a moisturizer at the same time. In some cases, you may need to decrease the dose or apply it every other day.

Are there any precautions I should take when using Ziana?
  1. You have to be careful and not let the medication get into the eyes, nose or mouth. If for some reason, the medication does get into your eyes or mouth, rinse thoroughly with running water for 5-10 minutes.
  2. Never apply Ziana gel on skin that is broken, dry, ulcerated or cut.
  3. Clindamycin is an antibiotic and in some people trace amount of the drug may be absorbed into the body and cause diarrhea.
  4. Tretinoin can make the skin sensitive to sunlight. Thus, if you go out, you must cover the body with a long sleeved garment, wear a sunscreen, avoid sun-tanning and use of sunlamps. If not, then it can result in a sunburn like effect.
  5. Do not apply any other skin cream, lotion or gel on the face for at least one hour before using Ziana.
  6. After application, avoid applying any skin care products for the next 2 hours.
  7. Tretinoin can make your skin weather sensitive so you will need to protect it from extremes of temperature such as wind, cold and heat.
Who should not use Ziana?

Because Ziana gel contains clindamycin, it is important that people with inflammatory bowel diseases like Crohn’s disease and ulcerative colitis not use the medication. In addition, individuals with an inflammatory condition of the intestine known as colitis should not use this medication. The reason is that clindamycin can worsen the diarrhea.

Can Ziana be combined with other acne medications?

In general, you should not combine medications to treat the same disorder. If you are on erythromycin for your acne, you should not combine it with Ziana. Using multiple medications to treat the same disorder usually increases the risk of side effects.

Can Ziana cause allergies?

Like any medication, there is a risk of allergy with Ziana. If you develop a skin rash, difficulty breathing, swelling around the face and lips and chest pain, seek immediate medical attention. In this case, the risk of allergic reaction is quite low.

Does Ziana work immediately?

In general, the benefits of Ziana are not immediate. When you first apply the treatment, your skin will become red and may start to peel off. This is only temporary and nothing to worry about. After a few days, the redness and itching will disappear. If the itching is moderate, you may apply a slight touch of a moisturizer. The acne lesions will start to fade and disappear after 2-4 weeks. Once the acne lesions have disappeared you will not need to use the medication anymore.

In general pregnant women should try and avoid all medications. Ziana is definitely not recommended during pregnancy and in breast feeding women. The drug has the potential to cause birth defects. If you intend to become pregnant or are pregnant you must tell your doctor before using Ziana.

How can one get Ziana?

Ziana is a prescription medication. You need to see your healthcare provider and get a prescription for the drug. Because of fake and counterfeit drugs, it is best to buy from a retail store or a reputable online pharmacy. This gel should be stored at room temperature away from heat, light and moisture. Do not place the medication in the fridge and keep it away from reach of children.

Can Ziana interact with other medications?

In general, the risk of interaction with other medications is low. The reason is that Ziana gel is applied on skin and very little is absorbed in to the body. But the potential for interaction is always present. Thus, before you are prescribed this drug, tell your doctor about all the medications, herbs, vitamins and supplements that you take. There is a generic formula which is cheaper than the brand name medication; it works just as well. Just ask the pharmacist. You can browse the web and read the reviews on Ziana. The majority of people who use it have found the medication to be effective for acne. In addition, most reviews indicate that the acne disappears fast and there is a low rate of recurrence.